Week 6 has already delivered drama, with Denver defeating Seattle 17–14 in overtime on Thursday night.
Now the attention turns to Sunday's matchups, where S³ is going against conventional wisdom in several games.
We're taking the winless Titans, backing Cleveland without Lamar Jackson on the opposite sideline, predicting New Orleans to revive its season, and calling for Las Vegas to stun Buffalo.
S³ OFFICIAL PREDICTIONS
| Matchup | S³ Winner | Final Score |
|---|---|---|
| Texans at Jaguars | Houston | 24–17 |
| Titans at Colts | Tennessee | 31–21 |
| Panthers at Eagles | Carolina | 31–10 |
| Steelers at Buccaneers | Pittsburgh | 27–20 |
| Ravens at Browns | Cleveland | 23–17 |
| Saints at Giants | New Orleans | 30–23 |
| Bears at Falcons | Chicago | 31–23 |
| Jets at Patriots | New England | 27–13 |
| Cardinals at Rams | Los Angeles | 34–14 |
| Chargers at Chiefs | Kansas City | 38–10 |
| Bills at Raiders | Las Vegas | 24–21 |
| Cowboys at Packers | Green Bay | 35–21 |
| Commanders at 49ers | San Francisco | 31–21 |
THE S³ UPSET WATCH
Cam Ward gets his breakout performance.
Indianapolis has struggled defensively, and Daniel Jones is showing signs of entering another inconsistent stretch. We're calling for Tennessee to finally put together four quarters of productive football and capture its first victory of 2026.
No Lamar Jackson. Big problem.
Tyler Huntley deserves credit for helping Baltimore win against Atlanta, but Cleveland presents a difficult divisional challenge. We're backing the Browns' defense to control this matchup.
Sometimes desperation is the deciding factor.
New Orleans has struggled, but the Saints enter this matchup needing a victory to keep their season alive. S³ believes that urgency makes the difference.
One of our boldest predictions.
Buffalo has the offensive firepower, but the Raiders have an opportunity to exploit its defensive vulnerabilities and pull off the upset at home.
THE OTHER HEADLINERS
Carolina 31, Philadelphia 10: The Eagles are simply dealing with too many significant injuries. Carolina has the offensive production to capitalize.
Chicago 31, Atlanta 23: Two statistically similar teams, but Chicago's stronger scoring defense gives the Bears the edge.
Kansas City 38, Los Angeles Chargers 10: Our most decisive prediction of the week. The Chiefs dominate at Arrowhead.
Los Angeles Rams 34, Arizona 14: Too much Rams firepower, and we're anticipating an Aaron Donald takeover performance.
Green Bay 35, Dallas 21: The Packers take care of business at Lambeau Field.
San Francisco 31, Washington 21: The 49ers remain undefeated, improving to a projected 6–0.
S³ FINAL WORD
Week 6 isn't about automatically selecting the teams with the better records.
It's about examining matchups, offensive and defensive production, quarterback availability, injuries and the circumstances surrounding each team.
Our biggest gamble? Tennessee scoring 31 points after producing just three against Houston.
Our most confident blowout prediction? Kansas City over the Chargers.
And our biggest defensive statement? Cleveland handing Baltimore its second loss of the season.
The numbers establish the foundation. The matchups determine the picks.
S³ | Sweet Science Sports
Independent Analysis. Performance-Based Predictions.
